There is a constant need for new delivery systems that can provide increased therapeutic benefits to the patients. Pulsatile drug delivery is one such system that, by delivering drug at the right time, right place, and in right amounts, holds good promises of benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension, etc.Sustained release formulations are not efficient in treating the diseases especially diseases with chronological pathopysiology, for which, pulsatile drug delivery is beneficial. Various methodologies are employed for developing pulsatile drug delivery like time controlled PDDS which includes delivery systems with rupturable coating layer or with erodible coating layers or with release plug controlling, stimuli induced PDDS less temperature induced and chemical stimuli induced systems and externally regulated system. Multiparticulate systems are useful for treatment of patients; due to their resulting high efficiency and robustness. There are various technologies present in the market based on the various methodologies. Pulsatile release systems should be promising in the future.
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